|
The Hottest
Research of 2006-07
by Christopher King
The Science
Watch® Newsletter
once again takes its annual look back at the hottest of recent
research. The first table below
lists the researchers who, during 2007, fielded the highest
numbers of Hot Papers published over the last two years. The
second table highlights
the papers published during 2007 (aside from reviews) that were
most cited by the end of the year.
For this latest annual roundup, Science
Watch slightly
changed the selection procedure for hot authors. Previously,
selection was based on reports tallied in a single bimonthly Hot
Papers file late in the year. This time, however, Science
Watch made a
special extraction to enumerate all occurrences of unique Hot
Papers through the first ten months of 2007.
Of this year’s crop of scientists, the top-most are familiar
names. A trio of high-energy physicists—Mikhail Kopytine,
Basanta K. Nandi, and Thomas Peitzmann—return from last year’s
roundup, again by virtue of their participation in not one but
two large, multiauthor experimental collaborations: PHENIX and
STAR at Brookhaven National Laboratory. For the three
scientists, their contributions to research published over the
last two years resulted in a dozen Hot Papers recorded during
2007. (The names on each tier of the table, incidentally, are
listed alphabetically.)
Just below the physicists is another return appearance by an
even more familiar name, who has become something of a fixture
on this annual list of hot authors: Osaka University’s Shizuo
Akira, who earns the distinction for a fourth year in a row,
thanks to 11 Hot Papers on pathogen recognition and other
aspects of the immune response.
Space scientist John A. Nousek of Penn State also contributed to
11 hot reports, on X-ray emissions and other phenomena related
to gamma-ray bursts. High-impact astrophysics accounted for
another place in the table, for Jon Brinkmann of the Apache
Point Observatory, New Mexico, with his participation on 10 Hot
Papers. Most of these are reports from the Sloan Digital Sky
Survey mission; one such paper can currently be found at #6 in
the latest Physics Top
Ten.
The next author on the list, cancer geneticist Carlo M. Croce of
Ohio State University, is interviewed in this issue and
discusses his research on microRNA, the subject of his 10 Hot
Papers over the last two years. In a similar vein, Howard Hughes
Medical Institute investigator Todd R. Golub fielded 10 Hot
Papers on gene expression in cancer.
The 10 hot reports featuring Columbia University’s Jeffrey
A. Lieberman center
on schizophrenia and
its treatment; Lieberman discussed his highly cited research in
a recent interview (Science Watch, 18[5]: 3-4, September/October
2007). And Harvard epidemiologist JoAnn Manson also
contributed to 10 Hot Papers, on topics that include hormone-replacement
therapy and
women’s health, risk factors for diabetes,
and diet supplementation in the prevention of cardiovascular
disease and cancer.
Of 2007’s non-review papers, none approached the late-year
citation total of a June Astrophysical
Journal Supplement Series report
from the Wilkinson Microwave Anisotropy Probe mission. This
paper currently crowns the Physics Top Ten and is discussed in
this issue by correspondent Simon Mitton.
Continuing its performance of recent years, the New
England Journal of Medicine registered
strongly in the year-end listing of papers, fielding 3 of the
top 5 papers, and 15 overall. Science and Nature each
scored with 6. Together, the three journals accounted for more
than 60% of 2007’s hottest papers.
Christopher King is the Editor of the Science
Watch® Newsletter.
|
Scientists with Multiple Hot Papers |
|
Name |
Institution |
Field |
No. of Hot Papers |
|
Mikhail Kopytine |
Kent State University |
Physics |
12 |
|
Basanta K. Nandi |
Indian Inst. Technol., Bombay |
Physics |
12 |
|
Thomas Peitzmann |
Utrecht University |
Physics |
12 |
|
Shizuo Akira [see
also | see
also | see
also] |
Osaka University |
Immunology |
11 |
|
John A. Nousek |
Pennsylvania State University |
Space Science |
11 |
|
Jonathan Brinkmann |
Apache Point Observatory |
Space Science |
10 |
|
Carlo M. Croce |
Ohio State University |
Cancer Genetics |
10 |
|
Todd R. Golub |
HHMI, Broad Institute Cancer |
Genetics |
10 |
|
Jeffrey A. Lieberman |
Columbia University |
Psychiatry |
10 |
|
JoAnn Manson |
Harvard University |
Epidemiology |
10 |
|
Source: Thomson Scientific Hot
Papers Database. |
|
The Red-Hot Research Papers of 2007 |
|
Rank |
Paper |
Citations |
|
1 |
D.N. Spergel, et
al., " Three-year Wilkinson
Microwave Anistropy Probe (WMAP)
observations: Implications for cosmology," Astrophys.
J. Suppl. Ser., 170(2): 377-408, June 2007. |
204 |
|
2 |
R.J. Motzer, et
al., "Sunitinib versus interferon alfa in
metastatic renal-cell carcinoma," New
Engl. J. Med., 356(2): 115-24, 11 January 2007. |
118 |
|
3 |
B. Escudier, et
al., "Sorafenib in advanced clear-cell renal-cell
carcinoma," New
Engl. J. Med., 356(2): 125-34, 11 January 2007. |
106 |
|
4 |
S.E. Nissen, K. Wolski, "Effect of
rosiglitazone on the risk of myocardial infarction and
death from cardiovascular causes," New
Engl. J. Med., 356(24): 2457-71, 14 June 2007. |
101 |
|
5 |
R. Sladek, et
al., "A genome-wide association study identifies
novel risk loci for type 2 diabetes,"Nature,
445(7130): 881-5, 22 February 2007. |
92 |
|
6 |
G.W. Stone, et
al., "Safety and efficacy of sirolimus- and
paclitaxel-eluting coronary stents," New
Engl. J. Med., 356(10): 998-1008, 8 March 2007. |
68 |
|
7 |
E.L. Eisenstein, et
al., "Clopidogrel use and long-term clinical
outcomes after drug-eluting stent implantation," JAMA,
297(2): 159-68, 10 January 2007. |
66 |
|
8 |
L.J. Scott, et
al., "A genome-wide association study of type 2
diabetes in Finns detects multiple susceptibility
variants," Science,
316(5829): 1341-5, 1 June 2007. |
57 |
|
9 |
C. Kimchi-Sarfaty, et
al., "A ‘silent’ polymorphism in the MDR1 gene
changes substrate specificity,"Science,
315(5811): 525-8, 26 January 2007. |
57 |
|
10 |
B. Lagerqvist, et
al., "Long-term outcomes with drug-eluting stents
versus bare-metal stents in Sweden," New
Engl. J. Med., 356(10): 1009-19, 8 March 2007. |
54 |
|
11 |
P.M.A. Calverley, et
al., "Salmeterol and fluticasone propionate and
survival in chronic obstructive pulmonary disease," New
Engl. J. Med., 356(8): 775-89, 22 February 2007. |
53 |
|
12 |
A. Kastrati, et
al., "Analysis of 14 trials comparing
sirolimus-eluting stents with bare-metal stents,"New
Engl. J. Med., 356(10): 1030-9, 8 March 2007. |
52 |
|
13 |
W.E. Boden, et
al., "Optimal medical therapy with or without PCI
for stable coronary disease," New
Engl. J. Med., 356(15): 1503-16, 12 April 2007. |
50 |
|
14 |
J. Hampe, et
al., "A genome-wide association scan of
nonsynonymous SNPs identifies a susceptibility variant
for Crohn disease in ATG16L1," Nature
Genetics, 39(2): 207-11, February 2007. |
50 |
|
15 |
E. Zeggini, et
al., "Replication of genome-wide association
signals in UK samples reveals risk loci for type 2
diabetes," Science,
316(5829): 1336-41, 1 June 2007. |
49 |
|
16 |
J. Daemen, et
al., "Early and late coronary stent thrombosis of
sirolimus-eluting and paclitaxel-eluting stents in
routine clinical practice: Data from a large
two-institutional cohort study," Lancet,
369(9562): 667-78, 24 February 2007. |
49 |
|
17 |
FUTURE II Study Group (L.L. Villa, et
al.), "Quadrivalent vaccine against human
papillomavirus to prevent high-grade cervical lesions," New
Engl. J. Med., 356(19): 1915-27, 10 May 2007. |
47 |
|
18 |
ENCODE Project Consortium (E. Birney, et
al.), "Identification and analysis of functional
elements in 1% of the human genome by the ENCODE pilot
project," Nature,
447(7146): 799-816, 14 June 2007. |
47 |
|
19 |
L. Mauri, et
al., "Stent thrombosis in randomized clinical
trials of drug-eluting stents," New
Engl. J. Med., 356(10): 1020-9, 8 March 2007. |
46 |
|
20 |
M. Obeid, et
al., "Calreticulin exposure dictates the
immunogenicity of cancer cell death," Nature
Medicine, 13(1): 54-61, January 2007. |
46 |
|
21 |
S.N. Willis, et
al., "Apoptosis initiated
when BH3 ligands engage multiple Bcl-2 homologs, not Bax
or Bak," Science,
315(5813): 856-9, 9 February 2007. |
45 |
|
22 |
W.A. High, et
al., "Gadolinium is detectable within the tissue of
patients with nephrogenic systemic fibrosis," J.
Am. Acad. Dermatol., 56(1): 21-6, January 2007. |
44 |
|
23 |
R.C. Bailey, et
al., "Male circumcision for HIV prevention in young
men in Kisumu, Kenya: a randomised controlled trial," Lancet,
369(9562): 643-56, 24 February 2007. |
43 |
|
24 |
T.M. Frayling, et
al., "A common variant in the FTO gene
is associated with body mass index and predisposes to
childhood and adult obesity," Science,
316(5826): 889-94, 11 May 2007. |
42 |
|
25 |
S.E. Nissen, et
al., "Effect of torcetrapib on the progression of
coronary atherosclerosis," New
Engl. J. Med., 356(13): 1304-16, 29 March 2007. |
42 |
|
26 |
C. Greenman, et
al., "Patterns of somatic mutation in human cancer
genomes," Nature,
446(7132): 153-8, 8 March 2007. |
42 |
|
27 |
C. Spaulding, et
al., "A pooled analysis of data comparing
sirolimus-eluting stents with bare-metal stents," New
Engl. J. Med., 356(10):
989-97, 8 March 2007. |
42 |
|
28 |
R.H. Gray, et
al., "Male circumcision for HIV prevention in men
in Rakai, Uganda: a randomised trial," Lancet,
369(9562): 657-66, 24 February 2007. |
41 |
|
29 |
A. Phrommintikul, et
al., "Mortality and target haemoglobin
concentrations in anaemic patients with chronic kidney
disease treated with erythropoietin: a meta-analysis," Lancet,
369(9559): 381-8, 3 February 2007. |
41 |
|
30 |
C.W. Li, et
al., "Identification of pancreatic cancer stem
cells," Cancer
Res., 67(3): 1030-7, 1 February 2007. |
41 |
|
31 |
L.M. Scott, et
al., "JAK2 exon
12 mutations in polysythemia vera and idiopathic
erythrocytosis," New
Engl. J. Med., 356(5): 459-68, 1 February 2007. |
41 |
|
32 |
D.R. Broome, et
al., "Gadodiamide-associated nephrogenic systemic
fibrosis: Why radiologists should be concerned," Am.
J. Roentgenol., 188(2): 586-92, February 2007. |
41 |
|
33 |
A.S. Boyd, et
al., "Gadolinium deposition in nephrogenic
fibrosing dermopathy," J.
Am. Acad. Dermatol., 56(1): 27-30, January 2007. |
41 |
|
34 |
K.K. Wong, et
al., "A comprehensive analysis of common
copy-number variations in the human genome," Am.
J. Human Genetics, 80(1): 91-104, January 2007. |
40 |
|
35 |
W. Xue, et
al., "Senescence and tumour clearance is triggered
by p53 restoration in murine liver carcinomas," Nature,
445(7128): 656-60, 8 February 2007. |
39 |
|
36 |
D. Dudziak, et
al., "Differential antigen processing by dendritic
cell subsets in vivo," Science,
315(5808): 107-11, 5 January 2007. |
39 |
|
37 |
L. Page, et
al., "Three-year Wilkinson
Microwave Anisotropy Probe (WMAP)
observations: Polarization analysis," Astrophys.
J. Suppl. Ser., 170(2): 335-76, June 2007. |
37 |
|
38 |
J.D. Rioux, et
al., "Genome-wide association study identifies new
susceptibility loci for Crohn disease and implicates
autophagy in disease pathogenesis," Nature
Genetics, 39(5): 596-604, May 2007. |
36 |
|
39 |
P.D. Home, et
al., "Rosiglitazone evaluated for cardiovascular
outcomes: an interim analysis," New
Engl. J. Med., 357(1): 28-38, 5 July 2007. |
35 |
|
40 |
Y. Zheng, et
al., "Interleukin-22, a T(H)17 cytokine, mediates
IL-23-induced dermal inflammation and acanthosis," Nature,
445(7128): 648-51, 8 February 2007. |
35 |
|
41 |
J.E. Green, et
al., "A 160-kilobit molecular electronic memory
patterned at 10(11) bits per square centimetre," Nature,
445(7126): 414-7, 25 January 2007. |
35 |
|
42 |
R. Liu, et
al., "The prognostic role of a gene signature from
tumorigenic breast-cancer cells," New
Engl. J. Med., 356(3): 217-26, 18 January 2007. |
35 |
|
SOURCE: Thomson Scientific Web
of Science®
(Citations recorded as of late December 2007) |
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